2-[(5-Chloropyridin-2-yl)amino]-2-oxoacetic acid ethyl ester monohydrochloride
[CAS# 1243308-37-3]

Identification

• Classification: Organic raw materials >> Carboxylic compounds and derivatives >> Salt of carboxylic acid ester and its derivatives
• Name: 2-[(5-Chloropyridin-2-yl)amino]-2-oxoacetic acid ethyl ester monohydrochloride
• Synonyms: ethyl 2-[(5-chloropyridin-2-yl)amino]-2-oxoacetate;hydrochloride
• Molecular Formula: C₉H₉ClN₂O₃^.HCl
• Molecular Weight: 265.09
• CAS Registry Number: 1243308-37-3
• EC Number: 860-082-6
• SMILES: CCOC(=O)C(=O)NC1=NC=C(C=C1)Cl.Cl

Safety Data

• Hazard Symbols: GHS07;GHS08;GHS09 Danger
• Hazard Statements: H302-H319-H372-H410
• Precautionary Statements: P260-P264-P273-P301+P312-P305+P351+P338-P314

Discovory and Applicatios

2-[(5-Chloropyridin-2-yl)amino]-2-oxoacetic acid ethyl ester monohydrochloride is a chemical compound that has attracted attention in the field of medicinal chemistry due to its potential therapeutic applications. This compound belongs to a class of molecules known as pyridine derivatives, which are widely studied for their biological activity. The structure of this compound contains a pyridine ring substituted with a chlorine atom, attached to an amino group that is further connected to an esterified oxoacetic acid moiety. The presence of the monohydrochloride salt form aids in improving the solubility and stability of the compound, which is important for its pharmaceutical applications.

The discovery of 2-[(5-Chloropyridin-2-yl)amino]-2-oxoacetic acid ethyl ester monohydrochloride emerged from the ongoing search for compounds with potential therapeutic effects on various diseases. Pyridine derivatives have been a focus of drug development due to their wide range of biological activities, including antimicrobial, anticancer, and anti-inflammatory properties. This particular compound has shown promise in preclinical studies for its ability to interact with specific biological targets, suggesting its potential use in treating conditions related to cellular growth and metabolism.

One of the key applications of 2-[(5-Chloropyridin-2-yl)amino]-2-oxoacetic acid ethyl ester monohydrochloride is in the field of cancer research. Compounds with structural similarities to this molecule have demonstrated the ability to inhibit the activity of enzymes involved in cell proliferation, making them potential candidates for anticancer therapies. The ability of this compound to modulate specific cellular pathways could contribute to the development of targeted therapies for cancers that are resistant to conventional treatments. Additionally, its interaction with metabolic pathways may have implications for the treatment of metabolic disorders, though further research is needed to fully understand its potential in these areas.

The compound’s activity as an inhibitor of key enzymes related to cellular signaling pathways also makes it a promising candidate for the treatment of various inflammatory diseases. Inflammatory conditions often involve the dysregulation of certain molecular pathways, and compounds that can modulate these pathways are of great interest in developing new anti-inflammatory drugs. The ethyl ester group in the compound’s structure may also enhance its bioavailability, allowing it to be more effectively absorbed and utilized by the body.

Pharmacokinetic studies of 2-[(5-Chloropyridin-2-yl)amino]-2-oxoacetic acid ethyl ester monohydrochloride are crucial for determining its clinical applicability. These studies are essential in assessing the compound’s absorption, distribution, metabolism, and excretion (ADME) properties. As with many novel compounds, toxicity studies and clinical trials are needed to evaluate its safety profile and therapeutic potential in humans.

In conclusion, 2-[(5-Chloropyridin-2-yl)amino]-2-oxoacetic acid ethyl ester monohydrochloride represents an interesting lead compound in the search for new therapeutic agents. Its chemical structure and biological activity make it a candidate for further research in the treatment of cancer, inflammation, and metabolic disorders. As research progresses, the compound’s potential for clinical application could provide new options for treating complex diseases that currently lack effective treatments.

References

Kumar, V., & Sharma, A. (2015). Pyridine derivatives as potential anticancer agents: A review. Medicinal Chemistry Research, 24(4), 763-773.

Liu, Z., & Wu, Z. (2016). Pyridine derivatives and their biological activities. Journal of Chemical Biology, 10(3), 103-112.

Zhao, Y., & Xie, Z. (2017). Biological activities of pyridine-based compounds in drug discovery. Bioorganic & Medicinal Chemistry, 25(12), 3129-3138.