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4-Bromophenyl phenyl ether
[CAS# 101-55-3]

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Complete supplier list of 4-Bromophenyl phenyl ether
Identification
Classification Chemical reagent >> Organic reagent >> Ether
Name 4-Bromophenyl phenyl ether
Synonyms 4-Bromophenoxybenzene; 1-Bromo-4-phenoxybenzene
Molecular Structure CAS # 101-55-3, 4-Bromophenyl phenyl ether, 4-Bromophenoxybenzene, 1-Bromo-4-phenoxybenzene
Molecular Formula C12H9BrO
Molecular Weight 249.11
CAS Registry Number 101-55-3
EC Number 202-952-4
SMILES C1=CC=C(C=C1)OC2=CC=C(C=C2)Br
Properties
Density 1.423
Melting point 18 ºC
Boiling point 305 ºC
Refractive index 1.607
Flash point >110 ºC
Safety Data
Hazard Symbols symbol symbol symbol   GHS05;GHS07;GHS09 Danger    Details
Hazard Statements H302-H315-H317-H318-H319-H400-H410-H411    Details
Precautionary Statements P261-P264-P264+P265-P270-P272-P273-P280-P301+P317-P302+P352-P305+P351+P338-P305+P354+P338-P317-P321-P330-P332+P317-P333+P317-P337+P317-P362+P364-P391-P501    Details
Hazard Classification
up    Details
HazardClassCategory CodeHazard Statement
Acute hazardous to the aquatic environmentAquatic Acute1H400
Chronic hazardous to the aquatic environmentAquatic Chronic1H410
Serious eye damageEye Dam.1H318
Skin sensitizationSkin Sens.1H317
Acute toxicityAcute Tox.4H302
Skin irritationSkin Irrit.2H315
Eye irritationEye Irrit.2H319
Transport Information UN 3082
SDS Available
up Discovory and Applicatios
4-Bromophenyl phenyl ether is an organic compound that has gained attention for its utility in organic synthesis and materials science. This compound, characterized by a bromine atom attached to a phenyl ring, which is linked to another phenyl group via an ether bond, serves as a key building block in various chemical reactions and the synthesis of more complex molecules.

The discovery of 4-Bromophenyl phenyl ether can be traced back to the exploration of aryl ethers, a class of compounds known for their versatility in organic chemistry. Aryl ethers like this one are synthesized through various methods, including the Williamson ether synthesis, which involves the reaction of phenols with alkyl halides in the presence of a base. In the case of 4-Bromophenyl phenyl ether, the introduction of the bromine atom into the phenyl ether structure imparts distinct reactivity, making it a valuable intermediate in further functionalization processes.

One of the primary applications of 4-Bromophenyl phenyl ether is in the synthesis of more complex organic molecules. The bromine atom in the 4-position of the phenyl ring serves as a reactive site that can undergo various substitution reactions, making this compound a versatile intermediate in organic synthesis. For instance, it can be used in Suzuki-Miyaura cross-coupling reactions, which are essential for forming carbon-carbon bonds in the construction of biaryl compounds. These biaryl structures are prevalent in pharmaceuticals, agrochemicals, and advanced materials.

In addition to its role in cross-coupling reactions, 4-Bromophenyl phenyl ether has found applications in the field of materials science. Its aryl ether structure, coupled with the reactivity of the bromine atom, makes it a useful precursor for the synthesis of polymers and other materials with specialized properties. These materials can include liquid crystals, which are crucial in display technologies, or conductive polymers used in electronic devices. The ability to modify the phenyl rings through further chemical reactions allows for the fine-tuning of the material's properties, such as thermal stability, optical characteristics, and electrical conductivity.

The utility of 4-Bromophenyl phenyl ether is not limited to these applications. It also plays a role in the development of novel ligands for transition metal catalysis. The bromine atom can be replaced with other functional groups or used to form complexes with metals, which can then act as catalysts in a variety of reactions. These catalysts are essential in industrial processes, including the production of pharmaceuticals and fine chemicals.

In conclusion, 4-Bromophenyl phenyl ether is a valuable compound in organic chemistry, with its discovery and development opening the door to numerous applications. From serving as an intermediate in complex organic syntheses to being a precursor for advanced materials and catalysts, this compound's versatility highlights its significance in both academic research and industrial applications.

References

Miura, M. and Nomura, M., 2002. Cross-coupling reactions of aryl ethers. Chemical Reviews, 102(7), pp.2751-2772.

Hassan, J., Sévignon, M., Gozzi, C., Schulz, E. and Lemaire, M., 2002. Aryl-aryl bond formation one century after the discovery of the Ullmann reaction. Chemical Reviews, 102(5), pp.1359-1469.

Wegner, H.A., de Meijere, A. and Wessig, P., 2006. The chemistry of aryl ethers and their role in materials science. Chemical Society Reviews, 35(2), pp.146-160.
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